Abstract / Excerpt:

Abstract: The study is an attempt towards the synthesis of 1H-indazoles. The reaction is believed to involve phenyldiazomethane as the intermediate when substituted benzaldehyde tosylhydrazones are treated with bases. Various synthetic transformation promoted by the reagent, p-tosylhydrazine, as well as the current synthesis methods of 1 H-indazoles, depending on the nature and type of the ring closure effected, are discussed. The tosylhydrazones of the aldehydes are formed in ethanol and the possibility of effecting the intramolecular cyclization is tried under different experimental conditions. Upon treatment with sodium carbonate in dioxan, the various tsylhydrazones yielded a mixture possibly containing p-toluenesulfonic and p-toluenesulfinic acids. In most of the cases, a complex mixture resulted, which could not be separated at our hands and their 'H-NMR spectra indicated the presence of the methyl of p-toluenesulfonyl group. In some cases, fractions devoid of the tosyl groups could be isolated and their structural confirmation is awaited.

Info

Source Institution	Ateneo de Davao University
Unit	Natural Science
Authors	Lim, Shirley G.
Page Count	1
Place of Publication	Manila
Original Publication Date	March 3, 1986
Tags	Chemistry, Dissertations

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